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  • DNA Day 18:31 on 12 March, 2010 Permalink | Reply  

    A Guide to DNA Day Session Files and Notes 

    Notes, photos, slide sets, and other materials from DNA Day 3/6 2010:

    Note from May 4 2010: we recently upgraded the system with which we publish this blog. The following presentations are temporarily unavailable while we complete the upgrade:

    • Understanding Multifactorial Traits through an Investigation of Smoking Behavior — Maureen Munn and Megan Brown, UW GS
    • Gene-Environment Interactions, Neurotransmission, and Drug Addiction — Maureen Munn and Megan Brown, UW GS

    Published before the event and still available:

    With the instructions on the right, anyone is welcome to be an author on this blog, and anyone is also welcome to leave a reply on any post.

     
    • Miami Caterers 11:23 on 24 August, 2010 Permalink | Reply

      It would be practical for a person who does not own a car to just go to car rentals and rent a good one to use. Although it is a bit costly, it is still a need since the car would be used. For fathers that still don’t have the money to buy new one, I’m sure a lot of them would go to car rentals and just rent one.

    • Weddings Fort Lauderdale 14:29 on 23 August, 2010 Permalink | Reply

      My boss owned a Toyota Hilux but it broke down when we traveled last month. We needed to make another travel and so one of my colleagues suggested that we would just rent a car. It was an option since we really need to make the trip. We were thankful that we got to rent a car.

    • Weddings Miami 09:19 on 21 August, 2010 Permalink | Reply

      When you are to have a wedding reception, choosing the right vendor to deal with, becomes a big task to take on.

    • Caterers in Palm Beach 14:42 on 20 August, 2010 Permalink | Reply

      I always enjoy going to the mountains and stay there in a cottage for a week to have some time for myself to run away from everything. It always calms me and it’s the only time when I get the opportunity to think about life in general and its value .

    • Miami Caterers 14:31 on 20 August, 2010 Permalink | Reply

      Jimmy and I were talking about our career , how long we’ve stayed for the company and life in general. Sometimes when you’re emotionally down and discontented with your life, its unavoidable to think about such things even in the workplace .

    • Miami dentist 14:28 on 20 August, 2010 Permalink | Reply

      My brothers and I were on a vacation to Texas when unexpectedly out of nowhere a tornado touched down near our vehicle. We all panicked but unbelievably we got out of the situation without harm. every so often, unexpected things happen which makes you feel lucky of being alive and be able to recognize the value of the beauty of life in general.

    • Miami caterer 09:18 on 20 August, 2010 Permalink | Reply

      My pals and I are thinking to watch a movie at the theatre next week and we decided to watch a new film about an elderly man visiting his children after his wife’s murder and life in general. The movie has good movie evaluation and it’s the only film within the season which we believed is worth watching.

  • Brian Glanz 18:00 on 6 March, 2010 Permalink | Reply
    Tags: , Cold Spring Harbor Laboratories, , , extraction, , , isolation, modeling, Nancy Hutchison, nucleotide bases, , protocol, RNA, SEP, Stephanie Namciu, Wellcome Trust Sanger Institute   

    DNA Isolation and Modeling 

    DNA Isolation and Modeling -- SEP -- FHCRC -- HHMI -- Hutchison and Namciu

    Science Education PartnershipToday we extract DNA from a strawberry and evaluate educational DNA models, courtesy of the Science Education Partnership (SEP), funded by the Fred Hutchinson Cancer Research Center and the Howard Hughes Medical Institute. Leading the activities and discussion are Dr. Nancy Hutchison, SEP Director and Dr. Stephanie Namciu, SEP Associate Director.

    Session files used in the protocol are available for download:

    DNA From Strawberries in PDF“Also works well with kiwi or bananas.”

    Strawberry DNA Teaching Overheads in PDF“A step-by-step explanation of the function of each ingredient in the lysis solution.”

    SEP are currently updating these and other educational materials at their web site.

    This entertaining and inexpensive protocol was adapted from Biotechnology in the Classroom, UC Davis and Diane Sweeney, Biology — Exploring Life. First we, the teacher-students line up for our materials: (View the full post …)

     
  • Brian Glanz 16:45 on 6 March, 2010 Permalink | Reply
    Tags: 23andMe, Bio-ITEST, , bioinformatics, , BLAST, causality, Cn3D, , , determinism, , , , genetic testing, , , mentors, , , , NOVA, , , professional development, , Punnett Squares, , , , STEM   

    Introduction to Bioinformatics 

    New Frontiers in Bioinformatics and Computational Biology -- Jeanne Chowning -- DNA-LEAP 2010

    Introduction to Bioinformatics -- Jeanne Chowning -- NWABR

    photo by Brian Glanz

    Jeanne Chowning, Director of Education at NWABR and Reitha S. Weeks, PhD., Resident Scientist at NWABR presented an introduction to bioinformatics and computational biology for high school educators.

    (View the full post …)

     
  • Brian Glanz 15:27 on 6 March, 2010 Permalink | Reply
    Tags: AIDS, Alma-Ata, anthropology, bacteria, behavior, communications, , drug resistance, ecology, economics, education, environment, fungi, , , , germs, GH, , H1N1, health, healthcare, HIV, immune evasion, , influenza, inheritance, Ken Stuart, linguistics, , nutrition, , , , public affairs, science, , SSGCID, TB, technology, , transportation, vaccines, , Watson and Crick   

    Watson & Crick’s Connections to Today’s Global Health Research 

    Watson & Crick’s Connections to Today’s Global Health Research Theresa Britschgi

    Theresa Britschgi, BioQuest Director at Seattle BioMed presents “Watson & Crick’s Connections to Today’s Global Health Research” for middle school educators. From our program’s description of this session:

    “Discussing DNA base pairing? Discover the answer to the reoccuring student question of “why do we need to know this?”. Scientists from Seattle Biomedical Research Institute will offer an introduction to the growing State industry cluster that is working on global health with specific examples on how a basic understanding of DNA fuels the underlying theory of the science that is tackling AIDS, TB, H1N1 and malaria today.”

    Britschgi shared the files from her session, including the main PowerPoint presentation. In this blog post, after linking to those files I will transcribe the main PowerPoint presentation into the post. (View the full post …)

     
  • Brian Glanz 13:35 on 6 March, 2010 Permalink | Reply
    Tags: , biomedical research, , ethical inquiry, fairness, , , justice, NCRR, , , objective, reasoning, resources, responsibility, , subjective, values   

    Introduction to Bioethics 

    Introduction to Bioethics -- Jeanne Chowning -- NWABR

    Jeanne Chowning, Director of Education at NWABR presented an introduction to bioethics for middle school educators. (View the full post …)

     
  • Brian Glanz 13:30 on 6 March, 2010 Permalink | Reply
    Tags: Adenine, Africa, agriculture, bed nets, CDC, , comparative analysis, controls, , Cylosine, databases, , , environmental studies, , expression levels, forensic science, fungus, , , , Guanine, , , , , microarrays, mosquitoes, mRNA, , parasites, , , , , , slides, stains, , Thymine, transcription, transcription rates, vaccine,   

    Use of DNA Microarrays in Malaria Research 

    Use of DNA of Microarrays in Malaria Research Theresa Britschgi

    Theresa Britschgi, BioQuest Director at Seattle BioMed presents “Use of DNA of Microarrays in Malaria Research” for high school educators. From our program’s description of this session:

    “Since the 2001 completion of the human genome draft sequence, scientists have been able to shift their focus to the ways in which organisms read the recipe of life and at what level of activity. Scientists from Seattle Biomedical Research Institute will offer classroom resources and training that will illuminate how microarrays work and the curriculum we offer will provide your students with an inspiring and relevent connection between DNA transcription and the content scientists use to battle malaria.”

    Britschgi shared the files from her session, including the main PowerPoint presentation. In this blog post, after linking to those files I will transcribe the main PowerPoint presentation into the post. (View the full post …)

     
  • Brian Glanz 12:40 on 6 March, 2010 Permalink | Reply
    Tags: , , , genetic variation, , , , , personalized medicine, prejudice, privacy, , public policy, ,   

    Communicating Breakthroughs in the Genomics Era 

    Dr. Edward Ramos at NWABR DNA Day 2010Dr. Ed Ramos delivered a masterful presentation on genomics for educators, of value not only for teachers and students but for everyone. He began with a review of basic genetics and genomics, illuminating the importance of recent and current work. By clearly explaining the science of human genetic variation, Ramos showed its personal and social relevance.

    With that primer, Dr. Ramos guided us through issues in science journalism, the socioeconomic impact of increasingly accessible genetic technology and knowledge, and both the promise and practical and ethical problems of communicating genetic information and probabilities to patients and the general public. Ramos ended by engaging ongoing debates in national public policy, with core issues ranging from the perils of prejudice and compromised privacy to our bright future in more efficient and personalized medicine.

    Dr. Ramos was insightful and motivating. I will publish my notes on his presentation, but I encourage everyone to download and review his slide set. There are roughly 50 slides and several with animations, I could not capture all of it in my notes.

    Dr. Ramos generously shared his presentation in two forms, PowerPoint 2007 and as a PDF. He requests that if you make use of or share these presentations, please retain the acknowledgements stated on the slides. Note also that Dr. Ramos added relevant websites to the “Notes” section of several slides in PowerPoint.

    Click these links to download:

    Dr. Ramos also shared a brief presentation of career resources prepared by Dr. Carla Easter, a science education specialist in NHGRI’s Education and Community Involvement Branch, which guides NHGRI’s National DNA Day. Download it by clicking: in PowerPoint — GenomicsCareerResource.ppt (View the full post …)

     
  • Brian Glanz 11:45 on 6 March, 2010 Permalink | Reply
    Tags: American Society of Human Genetics, , , BioQuest, , , , , , , , , , , ,   

    About DNA-LEAP and Introducing Dr. Ed Ramos 

    Jeanne Chowning, Director of Education at NWABR shares her appreciation for Amgen in not only hosting today’s DNA Day, but in collaborating many times with NWABR. Says Chowning, “Amgen have shown a lot of dedication to supporting outreach in our area.”

    Chowning describes the larger purpose of DNA Day, the national version of which is in April. She thanks the National Human Genome Research Institute and the National Institutes of Health for the financial support which made our regional DNA Day possible. Finally, she describes the history of those who have organized this event, LEAP — the Life Sciences Education Advancement Partnership, comprised of these partners: Seattle Biomedical Research Institute, BioQuest ProgramUniversity of Washington Department of Genome Sciences Education OutreachFred Hutchinson Cancer Research Center, Science Education Partnership; and the Northwest Association for Biomedical Research.

    LEAP is an informal partnership which began with a larger gathering in 2005, of nearly 100 outreach providers from our region, as covered here by the Puget Sound Business Journal in “Groups hope to attract next-gen bioscientists” and by two of today’s presenters, Seattle BioMed’s BioQuest Director, Theresa Britschgi and Chowning herself in “Increased science literacy a worthy goal for the Northwest” for the Seattle Post-Intelligencer.

    Our purposes here today include increasing understanding of genetics and genomics, and of the ethical issues inherent therein, and to introduce educators to resources for the future.

    After reviewing the contents of the folders we have all received today, our schedule, and other logistics, Chowning graciously introduces me and I tell everyone why I’m here. I will do my best to document today’s events and share its many resources here, both for service as a live blog today and as a living archive for future reference.

    Chowning then introduced today’s keynote speaker, Dr. Edward Ramos, Ph.D. — see his official biography in an earlier post on this blog. She emphasized his local connection and pointed out the exciting fact that students present here today, some active in programs such as BioQuest at Seattle BioMed and others studying now at the University of Washington, are following in Ramos’ footsteps. Quoting from the locally focused portion of Ramos’ biography:

    Dr. Ramos received a doctorate in molecular biotechnology from the University of Washington, Seattle, with a dissertation on chromosome dynamics carried out at the Fred Hutchinson Cancer Research Center in 2006. During his graduate studies, Dr. Ramos also focused on supporting and creating opportunities for underrepresented minorities in the sciences. He was an active participant in organizations and programs aimed at recruitment and retention of minorities in biomedical programs and other initiatives that provided exposure to young students interested in genetics and genomics. In 2006, he was awarded the American Society of Human Genetics/NHGRI Genetics and Public Policy Fellowship.

    —————————————-

    to the top of the NWABR DNA Day home page

     
  • Brian Glanz 11:30 on 6 March, 2010 Permalink | Reply
    Tags: , , inflammation, , nephrology, oncology,   

    Welcome to Amgen Seattle 

    Dr. Judy Fenyk-Melody welcomes and introduces us to Amgen, our excellent hosts today. Dr. Fenyk-Melody is Preclinical Director of Comparative Animal Research, she is site sponsor for the Amgen Women’s Interactive Network, and she serves on the Executive Board of Directors for the Northwest Association for Biomedical Research.

    An Introduction to Biotechnology

    Amgen have shared with everyone attending a printed copy of “An Introduction to Biotechnology” which you can download as a PDF, here: http://www.amgen.com/pdfs/misc/An_Introduction_Biotechnology.pdf

    “Amgen’s mission is to serve patients” Fenyk-Melody says, simply. The mission of this site, in Seattle is research, especially in inflammation, nephrology, and oncology (cancer medicine). Amgen were the first to discover, develop, and make protein-based medicines, though they are now modality independent.

    Their guiding principles are:

    • Focusing on serious illness
    • Being modality independent
    • Assessing efficacy in patients
    • Seamless integration from research to commercialization – or simply, “From Discovery to Patient”

    The Amgen Helix campus where we meet today spans 40 acres and 750,000 square feet, for nearly 1,000 staff.

    Dr. Fenyk-Melody also briefly describes the incredible investment required for Amgen’s products. Only 1 in 5,000 compounds are approved as medicine, and it typically takes 12 to 15 years from research to market.

    —————————————-

    to the top of the NWABR DNA Day home page

     
  • DNA Day 16:35 on 5 March, 2010 Permalink | Reply
    Tags: schedule   

    The General Schedule 

    Your specific schedule will vary per session, see the earlier blog post or if you’re here in person, see a handout.

    9:00 am Check-in, Welcome, Introductions, State Standards
    9:30 am Keynote Speaker: Ed Ramos, NHGRI
    10:30 am Break/Transition
    10:45 am Professional Development and Resources Breakout (Session 1)
    11:45 am Lunch and Posters
    12:30 pm Professional Development and Resources Breakout (Session 2)
    1:30 pm Break/Transition
    1:45 pm Professional Development and Resources Breakout (Session 3)
    2:45 pm Break/Transition
    3:00 pm Professional Development and Resources Breakout (Session 4)
    4:00 pm Closure/Evaluation
    5:00 pm Adjourn

    —————————————-

    to the top of the NWABR DNA Day home page

     
    • hills fan 12:24 on 28 July, 2010 Permalink | Reply

      Just cause you got the monkey off your back doesn’t mean the circus has left town.

      Sent from my iPhone 4G

  • Brian Glanz 16:31 on 5 March, 2010 Permalink | Reply
    Tags: session descriptions   

    Session Descriptions 

    Separate ‘strands’ are available for the Middle School/Introductory level and the High School level. Each participant will participate in four different, 1-hour sessions and learn about the resources offered by all the participating outreach groups.

    Professional development sessions will be offered by:

    Fred Hutchinson Cancer Research Center, Science Education Partnership

    DNA Isolation and Modeling (both Middle and High School strands) During the session presented by the Science Education Partnership (SEP) of Fred Hutchinson Cancer Research Center, workshop participants will isolate DNA from Strawberries. Then we will focus on DNA models that can be used in the classroom to aid students in their understanding of DNA structure. Participants will compare and contrast a variety of 3D models and websites, and create an origami model of the DNA double helix.

    Northwest Association for Biomedical Research

    Introduction to Bioethics (Middle School strand) This workshop will introduce a new introductory bioethics unit that helps teachers bring the discussion of challenging issues into their science classrooms. The materials build upon our widely-used Ethics Primer, highlighting the concepts and approaches that teachers have found most useful in promoting ethical analysis. The underlying importance of utilizing accurate scientific information in making informed decisions will be stressed. Tools for developing student understanding of the importance of strong justifications for positions will also be discussed. These strategies can be used generally to engage students in bioethical discussions that both support student engagement in science as well as promote an understanding of the role of science in society.

    Introduction to Bioinformatics (High School strand) This new curriculum unit explores the intersection of bioinformatics and genetic testing. Specifically, the bioinformatics tools of BLAST and Cn3D are used to investigate the genetic and molecular consequences of a mutation to the BRCA1 (breast cancer susceptibility) gene. Students are also introduced to principles-based bioethics in order to support their thoughtful consideration of the many social and ethical implications of genetic testing. In addition, students are presented with a number of career options throughout the unit in which the tools of bioinformatics are used.

    Seattle Biomedical Research Institute, BioQuest

    Watson & Crick’s Connections to Today’s Global Health Research (Middle School strand) Discussing DNA base pairing? Discover the answer to the reoccuring student question of “why do we need to know this?”. Scientists from Seattle Biomedical Research Institute will offer an introduction to the growing State industry cluster that is working on global health with specific examples on how a basic understanding of DNA fuels the underlying theory of the science that is tackling AIDS, TB, H1N1 and malaria today.

    Use of DNA Microarrays in Malaria Research (High School strand) Since the 2001 completion of the human genome draft sequence, scientists have been able to shift their focus to the ways in which organisms read the recipe of life and at what level of activity. Scientists from Seattle Biomedical Research Institute will offer classroom resources and training that will illuminate how microarrays work and the curriculum we offer will provide your students with an inspiring and relevent connection between DNA transcription and the content scientists use to battle malaria.

    Watch below for an early primer on this topic:

    YouTube Preview Image

    University of Washington, Department of Genome Sciences Education Outreach

    Understanding Multifactorial Traits through an Investigation of Smoking Behavior (Middle school strand) Many of the human traits that students find very interesting—intelligence, athleticism, musical ability, and behaviors such as addiction—are influenced by both genetic and environmental factors. These are called multifactorial traits. In this activity, students will look at the influence of genetic and environmental factors on smoking behavior, a multifactorial trait. The scenario, “If One Twin Smokes, Will the Other?” challenges students to consider how genes and environment might influence smoking behavior. Through the “Smoking Risk Game,” students learn that both genetic and environmental factors influence a person’s risk for being a smoker, but do not determine it.

    Gene-Environment Interactions, Neurotransmission, and Drug Addiction
    (High School strand) Smoking behavior can be described in terms of the stages of smoking, consisting of nonsmoking, initiation, maintenance, cessation, and relapse. Each stage is influenced by genetic and environmental factors. In this session, we will examine the profiles of several individuals to learn about the factors that influenced their smoking behavior. We will also discuss neurotransmission, the biology of addiction and how genes can influence smoking behavior. We will play the “Smoking Risk Game,” which demonstrates that both genetic and environmental factors influence a person’s risk for being a smoker, but do not determine it. These activities are part of the Investigating Smoking Behavior curriculum, a high school science curriculum that enables students, in the context of their science class, to conduct authentic human subjects research related to smoking behavior. We will discuss the research project and upcoming workshops.

    —————————————-

    to the top of the NWABR DNA Day home page

     
  • DNA Day 09:50 on 2 March, 2010 Permalink | Reply
    Tags: CRGGH, , ,   

    About Edward Ramos, Ph.D. 

    Edward Ramos, Ph.D.We are excited to announce Edward Ramos, Ph.D., research fellow and a science policy analyst at the National Human Genome Research Institute, Center for Research on Genomics and Global Health, National Institutes of Health, as our keynote speaker.

    Edward Ramos, Ph.D. is a research fellow and a science policy analyst at the National Human Genome Research Institute (NHGRI), National Institutes of Health (NIH). Dr. Ramos has a role in NHGRI’s Office of the Director, as well as for the trans-NIH Center for Research on Genomics and Global Health (CRGGH). He is involved in projects focused on understanding the role of genomics in health disparities, identifying the societal implications of genomics, and analyzing the health care and science policies relevant to these issues. Much of his work draws from the investigation of human genetic variation (from both a basic science and social science perspective) and its potential link to health and disease. His current research at the CRGGH includes a new collaborative genome-wide association study to identify variants associated with type 2 diabetes in Mexican Americans.

    Dr. Ramos received a doctorate in molecular biotechnology from the University of Washington, Seattle, with a dissertation on chromosome dynamics carried out at the Fred Hutchinson Cancer Research Center in 2006. During his graduate studies, Dr. Ramos also focused on supporting and creating opportunities for underrepresented minorities in the sciences. He was an active participant in organizations and programs aimed at recruitment and retention of minorities in biomedical programs and other initiatives that provided exposure to young students interested in genetics and genomics. In 2006, he was awarded the American Society of Human Genetics/NHGRI Genetics and Public Policy Fellowship. The fellowship was carried out in the Policy and Program Analysis Branch of NHGRI, and the congressional component in the Office of United States Senator Barack Obama. After completing his fellowship, he worked on the professional staff of then Senator Obama advising on health and science policy as a legislative assistant.

    —————————————-

    to the top of the NWABR DNA Day home page

     
  • DNA Day 09:42 on 2 March, 2010 Permalink | Reply
    Tags: , , , ,   

    About NWABR DNA Day 

    DNA-LEAP Educator Symposium
    Saturday, March 6th
    9:00am-5:00pm
    Amgen Seattle

    A day-long symposium providing professional development and curriculum related to genetics and genomics to middle and high school science teachers, presented by a collaboration of outreach providers.

    DNA-LEAP is the DNA Life Sciences Education Advancement Partnership, made possible by the support of a 2010 DNA Day award to NWABR from the National Human Genome Research Institute at the National Institutes of Health.

    LEAP partners include: Seattle Biomedical Research Institute, BioQuest Program; University of Washington Department of Genome Sciences Education Outreach; Fred Hutchinson Cancer Research Center, Science Education Partnership; and the Northwest Association for Biomedical Research. (View the full post …)

     
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